Determinants of Users Intention to Adopt Mobile Fitness Applications: an Extended Technology Acceptance Model Approach

The present research was motivated by the recognition that the use of mobile fitness applications (MFA) is increasingly popular among sports and exercise participants in recent years. Using an extended Technology Acceptance Model (TAM) perspective, this study explored potential predictors of behavioral intention toward MFAs such as perceived ease of use, perceived usefulness, personalization, personal innovativeness in information technology (PIIT), perceived enjoyment, mobile application self-efficacy, involvement in sports and exercise participation, and social influences (interpersonal and external influences). A theoretical model was developed and tested against the empirical data collected from 385 collegiate students enrolled in physical activity classes at a large university in the United States. The result of descriptive statistics indicated that the samples are active sports and exercise participants with their weekly exercise and sports participation of 5.41 hours. A measurement model and structural equation model were tested using AMOS 22.0 and confirmed eight out of eleven hypothesized relationships. In particular, personalization and PIIT were found to have significant effects on perceived usefulness and perceived ease of use, which in turn, affected behavioral intention toward using MFAs. Interpersonal influence and involvement in sports and exercise participation were also found to have significant effects on intention whereas no significant effects of mobile application self-efficacy, perceived enjoyment, and external influence were observed. The analyses demonstrated that perceived usefulness was the most powerful determinants of behavioral intention followed by interpersonal influence in terms of the path coefficient values. The construct of PIIT and personalization accounted for 43.4% variances in perceived ease of use and 48.9% variances in perceived usefulness variance. All the constructs within the structural model except external influence, perceived enjoyment, and mobile application self-efficacy, collectively explained the 75.1 % variances in intention to use MFAs, suggesting that the examined model has a strong explanatory power regarding MFA users decision making process.\u2

Impact of Pediatric Alopecia Areata on Quality of Life of Patients and Their Family Members: A Nationwide Multicenter Questionnaire Study

Background: Pediatric alopecia areata (AA) can affect the quality of life (QoL) of patients and their family members. Research on the QoL and burden on family members in pediatric AA is limited. Objective: This nationwide multicenter questionnaire study described the QoL and burden of the family members of patients with pediatric AA. Methods: This nationwide multicenter questionnaire study enrolled AA patients between the ages of 5 and 18 years from March 1, 2017 to February 28, 2018. Enrolled patients and their parents completed the modified Children's Dermatology Life Quality Index (CDLQI) and the modified Dermatitis Family Impact (mDFI). The disease severity was measured using the Severity of Alopecia Tool (SALT) survey scores. Results: A total of 268 patients with AA from 22 hospitals participated in this study. Our study found that the efficacy and satisfaction of previous treatments of AA decreased as the severity of the disease increased. The use of home-based therapies and traditional medicines increased with the increasing severity of the disease, but the efficacy felt by patients was limited. CDLQI and mDFI scores were higher in patients with extensive AA than those with mild to moderate AA. The economic and time burden of the family members also increased as the severity of the disease increased. Conclusion: The severity of the AA is indirectly proportional to the QoL of patients and their family members and directly proportional to the burden. Physicians need to understand these characteristics of pediatric AA and provide appropriate intervention to patients and their family members.N

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field